Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism |
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Authors: | Mashino T Okuda K Hirota T Hirobe M Nagano T Mochizuki M |
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Affiliation: | Kyoritsu College of Pharmacy, Tokyo, Japan. |
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Abstract: | Cationic ammonium fullerene derivatives (C60-bis(N, N-dimethylpyrrolidinium iodide) and C60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives. |
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