Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium |
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| Authors: | Salonen Jukka T Uimari Pekka Aalto Juha-Matti Pirskanen Mia Kaikkonen Jari Todorova Boryana Hyppönen Jelena Korhonen Veli-Pekka Asikainen Janne Devine Christopher Tuomainen Tomi-Pekka Luedemann Jan Nauck Matthias Kerner Wolfgang Stephens Richard H New John P Ollier William E Gibson J Martin Payton Antony Horan Michael A Pendleton Neil Mahoney Walt Meyre David Delplanque Jerôme Froguel Philippe Luzzatto Oren Yakir Benjamin Darvasi Ariel |
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| Institution: | Oy Jurilab, and Research Institute of Public Health, University of Kuopio, Kuopio, Finland, and Hope Hospital, Salford, UK. |
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| Abstract: | Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. |
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