首页 | 本学科首页   官方微博 | 高级检索  
     

急性脊髓损伤后大鼠电刺激运动诱发电位的变化
引用本文:Yu KW,Ye XJ,Li JS,Rong WF,Ja LS,He HL. 急性脊髓损伤后大鼠电刺激运动诱发电位的变化[J]. 中国应用生理学杂志, 2002, 18(1): 14-17
作者姓名:Yu KW  Ye XJ  Li JS  Rong WF  Ja LS  He HL
作者单位:1. 第二军医大学长征医院骨科,上海,200003
2. 第二军医大学生理教研室,上海,200433
基金项目:上海市医学领先专业重点学科基金资助项目 ( 1995 Ⅲ 0 0 8)
摘    要:目的:比较不同程度脊髓损伤(SCI)与运动诱发电位(MEP)变化之间的关系,探索MEP检查在SCI早期诊断及预后中的价值。方法:27只雄性SD大鼠以改良Allen‘s打击法致伤T8-T9脊髓,按打击冲量随机分为空白对照组(n=5),SCI A组(50gcf,n=8),SCI B组(70gcf,n=8)和SCI C组(100gcf,n=6),采用单极经皮层电刺激,分别于损伤前、伤后即刻、15min、30min、1h、3h和6h连续观察scMEP变化,并计算脊髓出血坏死区域占脊髓横截面积的比率。结果:对照组MEP无显著改变,SCI A组和SCI B组动物MEP早成份波幅立即减低或消失,以后有所恢复,晚成份波消失后未再出现。SCI C组动物除2只大鼠SCI后MEP仍有所恢复外,其余动物再未出现MEP波。脊髓损伤随打击冲量增大而增加,与伤后1h scMEP最大波幅呈显著相关(r=-0.821)。结论:SCI后scMEP的变化程度与打击冲量和脊髓病理损伤面积相关,提示scMEP可以作为一种脊髓功能检测的客观指标。

关 键 词:运动诱发电位 电刺激 脊髓损伤 大鼠
文章编号:1000-6834(2002)01-0014-04
修稿时间:2000-10-13

Changes of motor evoked potentials after spinal cord injuries in rats
Yu Ke-Wei,Ye Xiao-Jian,Li Jia-Shun,Rong Wei-Fang,Ja Lian-Shun,He Hai-Long. Changes of motor evoked potentials after spinal cord injuries in rats[J]. Chinese journal of applied physiology, 2002, 18(1): 14-17
Authors:Yu Ke-Wei  Ye Xiao-Jian  Li Jia-Shun  Rong Wei-Fang  Ja Lian-Shun  He Hai-Long
Affiliation:YU Ke-wei 1,YE Xiao-jian 1,LI Jia-shun 1,RONG Wei-fang 2,JA lian-shun 1,HE Hai-long 1
Abstract:Aim:Study on the relationship between the degraded spinal cord injuries and the changes of the motor evoked potentials (MEP) to prove the diagnosis and prognosis value of MEP. Methods:After injury at T 8-T 9 cord using modified Allen's weight-drop method, 27 male SD rats were divided randomly into control group (n=5), group A (50 gcf, n=8), group B (70 gcf,n=8) and group C (100 gcf, n=6). MEPs elicited by monopolar transcortical stimulation were recorded continuously before injury, just after injury, 15 minutes, 1 hour, 3 hours and 6 hours after injury. The rate of the size of the bleeding or necrosis area to the total cord was also calculated. Results: MEP had no significant change in the control group. The amplitude of MEP's early components in group A or group B decreased or even obliterated after SCI, and then partially recovered, while the late components were lost without any recovery signals. All animals in group C showed no MEP waves excepting 2 rats had recovery signals. The size of the cord injuried area increased according to the dropping force and was correlated significantly with the amplitude of the largest peaks of scMEP 1 hour after SCI (r=-0.821). Conclusion: The scMEP changes after SCI are correlated with the injury forces and the pathological changes in the cord, which indicates that scMEP can be used as an objective index for the cord functional monitoring.
Keywords:motor evoked potentials  electric stimulation  spinal cord injuries  rats
本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号