Cytotoxic isoflavones from Erythrina indica. |
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| Authors: | A E Nkengfack A G Azebaze A K Waffo Z T Fomum M Meyer F R van Heerden |
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| Institution: | Department of Organic Chemistry, Faculty of Science University of Yaounde I, PO Box 812 Yaounde, Cameroon. ankengf@uycdc.uninet.cm |
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| Abstract: | Bioassay-directed fractionation of the CH(2)Cl(2)-MeOH (1:1) extract of the stem bark of Erythrina indica, has resulted in the isolation of two new isoflavone derivatives named indicanines D and E together with 11 known compounds including: six isoflavones (genistein, wighteone, alpinumisoflavone, dimethylalpinumisoflavone, 8-prenyl erythrinin C, and erysenegalensein E), one cinnamate (erythrinassinate B), two pentacyclic triterpenes (oleanolic acid and erythrodiol), and two phytosterols (stigmasterol and its 3-O-beta-D-glucopyranoside). The structures of the new compounds were elucidated by means of spectroscopic analysis. The in vitro cytocidal activity against KB cells of some of the isolated compounds is also reported. |
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