The origin of HbS in Sicily: A toponymic study |
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Authors: | I Barrai |
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Institution: | (1) Dip. di Biologia Evolutiva Sez. di Genetica, Università di Ferrara, Via Borsari 46, 44100 Ferrara, Italy |
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Abstract: | The population structure of two alleles similarly affected by selection, HbS and Beta-thalassemia, was studied in the same
area, in Sicily. It was observed that Beta-thalassemia has uniform frequencies over the island, and that HbS shows a South-North
cline. A singularity exists for HbS, in the twon of Butera, where the frequency of the S gene is six times higher than the
island average. It was advanced that probably HbS entered Sicily from North Africa, when the Beta-thalassemia allele was already
established in the Island. From the correlation analysis concluded that HbS came to Sicily with the frequency of HbS, it was
concluded that HbS came to Sicily before the Arab invasions of the 700 's AD. |
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Keywords: | HbS-Beta thalassemia Sicily Greece Arab invasions |
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