PHGDH amplification and altered glucose metabolism in human melanoma |
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Authors: | Mullarky Edouard Mattaini Katherine R Vander Heiden Matthew G Cantley Lewis C Locasale Jason W |
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Affiliation: | Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. |
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Abstract: | The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare. However, an enzyme involved in the de novo synthesis of serine, 3-phosphoglycerate dehydrogenase (PHGDH), was recently identified as a putative oncogene. The potential mechanisms by which PHGDH promotes cancer are discussed. |
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Keywords: | PHGDH serine biosynthesis cancer metabolism 3‐phosphoglycerate glycolysis |
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