Genomics of TGF-β1 signaling in stem cell commitment and dendritic cell development |
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Authors: | David Ruau Xin-Sheng Ju Martin Zenke |
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Affiliation: | aInstitute for Biomedical Engineering, Department of Cell Biology, Aachen University Medical School, Pauwelsstrasse 30, 52074 Aachen, Germany;bHelmholtz Institute for Biomedical Engineering, RWTH, Pauwelsstrasse 20, 52074 Aachen, Germany |
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Abstract: | Dendritic cells are professional antigen presenting cells and central for establishing and maintaining immunity and immunological tolerance. They develop from hematopoietic stem cells through successive steps of lineage commitment and differentiation. Dendritic cell development and function are regulated by specific cytokines, including transforming growth factor type β1 (TGF-β1). Our previous work demonstrated the importance of TGF-β1 signaling for dendritic cell development and subset specification. Here, we used genome-wide gene expression profiling with DNA microarrays to investigate the activity of TGF-β1 on gene expression in dendritic cell development. This study identified specific gene categories induced by TGF-β1 with an impact on dendritic cell biology. |
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Keywords: | Dendritic cells Stem cells Transforming growth factor TGF-β 1 DNA microarrays Gene expression profiling |
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