Serum T4, T3 and reverse T3 in ethanol fed rats. |
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| Authors: | S P Singh D G Patel M Kabir B N Premachandra |
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| Affiliation: | Veterans Administration Medical Center, North Chicago, Illinois and St. Louis, Missouri and St. Louis University School of Medicine St. Louis, Missouri, USA |
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| Abstract: | To investigate the influence of chronic ethanol consumption on circulating thyroid hormone levels, male and female rats were given 20% ethanol as the only drinking solution daily for 8 weeks. Blood ethanol levels ranged 30–45 mg/L. In male rats serum T4 decreased from the initial mean ± SD value of 5.2±1.4 to3.0 ±0.7 μg/dl; T3 decreased from initial value of 97±14 to 66±11 ng/dl and rT3 decreased from initial value of 19±9 to 10±1 ng/dl after 8 weeks of ethanol ingestion. Under similar experimental conditions, female rats showed a significant decrease in serum T4 and rT3 levels; however, T3 levels decreased slightly but not significantly as compared to initial values. The results indicate adverse effect of chronic ethanol intake on serum thyroid hormone levels in rats. |
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