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The H-mshi antigen is conserved among standard BALB/cBy, C57BL/6J, and wild-derived CAST/Ei and SPRET/Ei inbred strains of mice
Authors:Audrey L. Hildebrandt  Angelene M. Cantwell  Michael C. Rule  T. R. King
Affiliation:(1) Department of Biological Sciences, Central Connecticut State University, 1615 Stanley Street, New Britain, CT 06050, USA e-mail: kingt@ccsua.ctstateu.edu, Tel.: +1-860-832-2654, Fax: +1-860-832-2594, US
Abstract: The recessive male sterility and histoincompatibility mutation (mshi) arose spontaneously in the standard inbred mouse strain BALB/cBy. In addition to generating sterility in homozygous males, mshi controls the loss of a minor histocompatibility antigen designated H-mshi. To determine whether the H-mshi antigen normally expressed by the BALB/cBy strain (H-mshic) is the same as or different from the antigen (H-mshix) expressed by the standard inbred C57BL/6J strain or the wild-derived CAST/Ei and SPRET/Ei strains, animals heterozygous for the mutant antigen-loss allele (H-mshi ) and H-mshi x were grafted with tail skin from BALB/cBy mice. The long-term retention of grafts by these hosts indicates that the H-mshi antigen encoded by the BALB/cBy, C57BL/6J, CAST/Ei, and SPRET/Ei strains is histogenically identical. Conservation of this minor histocompatibility antigen among these evolutionarily diverse strains suggests that H-mshi encodes a functionally important cellular product(s). Received: 1 August 1998 / Accepted: 26 October 1998
Keywords:  Minor histocompatibility  Skin grafting  Antigen conservation  mshi mutation  Inbred mice
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