Structure-based design and synthesis of HIV-1 protease inhibitors employing beta-D-mannopyranoside scaffolds |
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| Authors: | Murphy Paul V O'Brien Julie L Gorey-Feret Lorraine J Smith Amos B |
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| Affiliation: | Chemistry Department, Centre for Synthesis and Chemical Biology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. paul.v.murphey@ucd.ie |
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| Abstract: | A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing beta-D-mannopyranoside scaffolds is given. The compounds prepared had IC(50) values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases. |
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