NaCl induced ornithine decarboxylase and DNA synthesis in rat stomach mucosa |
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| Authors: | C Furihata Y Sato M Hosaka T Matsushima F Furukawa M Takahashi |
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| Affiliation: | 1. Department of Molecular Oncology, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108, Japan;2. Department of Pathology, National Institute of Hygienic Sciences, Kamiyoga, Setagaya-ku, Tokyo 158, Japan |
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| Abstract: | A sensitive method is described that detects an alteration in the structure of tRNA that is caused by cadmium but not by magnesium or zinc ions. The chromatographic system, RPC-5, separates Drosophila tyrosyl-tRNA into two fractions. These two isoacceptors differ by a single position in the anticodon where either a guanosine or queuine resides. Cadmium ions apparently interact with the tRNA and prevent the chromatographic separation. This is the first instance where cadmium is shown to cause a selective change in nucleic acid structure. The RPC-5 system seems to be uniquely useful in detecting such a change. |
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| Keywords: | DAP 1,3-diaminopropane dThd thymidine MNNG N-methyl-N′-nitro-N-nitrosoguanidine ODC ornithine decarboxylase TPA 12-O-tetradecanoyl-phorbol-13-acetate |
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