The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy

Authors:	Hyun?Wook?Cho,Rong?Nie,Kay?Carnes,Qing?Zhou,Noaman?AQ?Sharief,Rex?A?Hess author-information" > author-information__contact u-icon-before" > mailto:rexhess@uiuc.edu" title=" rexhess@uiuc.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Reproductive Biology & Toxiology, Veterinary Biosciences, University of Illinois, 2001 S. Lincoln, 61802 Urbana, IL, USA;(2) Department of Biology, Sunchon National University, 540-742 Sunchon, South Korea, USA

Abstract:	Background Estrogen receptors (ER) have important physiological roles in both the female and male reproductive systems. Previous studies using the estrogen receptor-α knockout mouse (αERKO) or antiestrogen treatment in adult rodents have shown that ERα is essential for normal function of the male reproductive tract. In the present study, time-response effects of the antiestrogen ICI 182,780 were determined to better understand ERα function in the adult male.

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