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Interactions of ouabain and vanadate with (Na+,K+)ATPase and isolated cardiac muscle |
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| Authors: | T D Myers R C Boerth |
| Institution: | 1. Department of Pharmacology Vanderbilt University School of Medicine Nashville, Tennessee 37232 USA;2. Department of Pediatrics Vanderbilt University School of Medicine Nashville, Tennessee 37232 USA |
| Abstract: | The interactions of ouabain and vanadate with (Na+,K+)ATPase were investigated at different potassium concentrations. Also, the contractile effects of a mixture of these two inhibitors were compared to those produced by ouabain or vanadate alone. The results from the enzyme and contractile studies suggested that inhibition of sarcolemmal (Na+,K+)ATPase was involved in mediating the positive inotropic effect of vanadate. |
| Keywords: | Address correspondence and reprint requests to Timothy D Myers Section of Cardiovascular Sciences Department of Medicine Baylor College of Medicine Houston Texas 77030 |
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