Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis |
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Authors: | Michael K Boettger Johannes Leuchtweis Diana Kümmel Mieczyslaw Gajda Rolf Br?uer Hans-Georg Schaible |
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Affiliation: | 1.Institute of Physiology I/Neurophysiology Jena University Hospital - Friedrich Schiller University, Teichgraben 8, D-07743 Jena, Germany;2.Institute of Pathology, Jena University Hospital - Friedrich Schiller University, Ziegelmühlenweg 1, D-07743 Jena, Germany |
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Abstract: | Introduction Interleukin-6 (IL-6) is a key player in systemic arthritis, involved in inflammation and joint destruction. IL-6 signalling has also been revealed in nerve cells. Recently, IL-6 and in particular IL-6 together with its soluble IL-6 receptor (sIL-6R) were shown to induce a long-lasting robust sensitization of joint nociceptors for mechanical stimuli which was difficult to reverse, suggesting that IL-6 signalling plays a significant role in the generation and maintenance of arthritic pain. Here we tested in a preclinical model of arthritis, antigen-induced arthritis (AIA) in the rat, whether systemic or local neutralization of IL-6/sIL-6R complexes with soluble glycoprotein 130 (sgp130) alters arthritic pain and how sgp130 influences the inflammatory process in AIA. |
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