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RuII(NO+)]3+-core complexes with 4-methyl-pyrimidine and ethyl-isonicotinate: synthesis, X-ray structure, spectroscopy, and computational and NO-release studies upon UVA irradiation |
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| Authors: | Tamasi Gabriella Curci Matia Berrettini Francesco Justice Nicholas Sega Alessandro Chiasserini Luisa Cini Renzo |
| Institution: | a Department of Chemical and Biosystem Sciences and Technologies, University of Siena, Via A. Moro 2, I-53100 Siena, Italy b Center for Analysis and Structural Determination, University of Siena, Via A. Moro 2, I-53100 Siena, Italy c Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA d Department of Medicinal Chemistry, University of Siena, Via A. Moro 2, I-53100 Siena, Italy |
| Abstract: | The reaction of RuCl(3)(NO).H(2)O with 4-methylpyrimidine (MePYM) and ethylisonicotinate (EINT), in absolute ethanol at 40-55 degrees C afforded crystalline trans-RuCl(3)(NO)L(2)] complexes. Structural studies via X-ray diffraction, and spectroscopic methods (NMR, IR, UV-visible (UV-Vis)) revealed that the molecular structures have the two Ls in trans positions (axial) and the chloride anions and the NO(+) cation as equatorial ligands; pyrimidine...pyrimidine pairing pattern via two weak C-H...N interactions occur. The molecular structures for the EINT derivative was inferred from spectroscopy and computations. Under irradiation at 366 nm several solutions of the title compounds deliver NO via first order processes. Visible light (420-700 nm) does not produce significant NO release from CH(2)Cl(2) and CH(3)CN solutions within 24h. |
| Keywords: | Ruthenium Nitric oxide Pyrimidine Isonicotinate Photo-reactivity |
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