Synthesis, crystal structure, antibacterial assay and DNA binding activity of new binuclear Cu(II) complexes with bridging oxamidate |
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Authors: | Song Yu-Lan Li Yan-Tuan Wu Zhi-Yong |
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Affiliation: | Marine Drug and Food Institute, Ocean University of China, Yushan Road No. 5, Qingdao, Shandong 266003, PR China |
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Abstract: | Two new binuclear copper complexes, [Cu2(oxpn)(bpy)(pic)(H2O)](pic) (1) and [Cu2(oxpn)(Me2bpy)(pic)](pic) (2) [H2oxpn = N,N′-bis(3-aminopropyl)oxamide; Hpic = 2,4,6-trinitrophenol; bpy = 2,2′-bipyridine; Me2bpy = 4,4′-dimethyl-2,2′-bipyridine], have been synthesized and characterized by elemental analyses, conductivity measurements, IR, UV-visible spectroscopy and single crystal X-ray analyses. Both complexes have similar molecular structures. In complex 1, the central two Cu(II) atoms are bridged by cis-oxpn2− with the Cu1-Cu2 separation of 5.221 Å and the polyhedron of each copper atom is a square-pyramid. Similarly, complex 2 is a cis-oxpn2−-bridged binuclear complex with the Cu1-Cu2 separation of 5.196 Å. Cu1(II) central atom situated in a tetrahedral geometry is four-coordinated and Cu(II) atom situated in a square-pyramidal geometry is five-coordinated. Hydrogen bonding interactions and π-π stacking interactions link the binuclear copper complex 1 or 2 into a 2D infinite network. The antibacterial assays indicate that the two complexes showed better activities than their ligands. The interactions of the two binuclear complexes with herring sperm DNA (HS-DNA) have been studied by UV absorption titration, fluorescence titration and viscosity measurements. The results suggest that the two binuclear complexes bind to HS-DNA via an intercalative mode. |
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Keywords: | Binuclear Cu(II) complex Oxamido-bridging Crystal structure Antibacterial activity DNA-binding |
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