In vitro studies with rifampicin on the stability of heart mitochondrial RNA |
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| Authors: | J G Gamble R H McCluer |
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| Affiliation: | 1. Biophysical Chemistry Laboratory, Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi 110025, India;2. Department of Chemistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia;3. Surface Chemistry and Catalytic Studies group, SCCS, Department of Chemistry, King Abdulaziz University, Jeddah 21589, Saudi Arabia;1. Aix Marseille Univ, CNRS, Centrale Marseille, M2P2, Marseille, France;2. Polymers & Composites, Council for Scientific & Industrial Research (CSIR), PO Box 395, Pretoria, South Africa |
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| Abstract: | Bovine heart mitochondria synthesize stable and unstable RNA in vitro, and low doses of rifampicin inhibit this synthesis. The unstable RNA directs the incorporation of [14C]leucine into mitochondrial protein and has a half-life of 1.4 minutes. |
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