Natural inhibitors targeting osteoclast-mediated bone resorption |
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Authors: | Zeng Guang-Zhi Tan Ning-Hua Hao Xiao-Jiang Mu Quan-Zhang Li Rong-Tao |
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Institution: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China; Graduate School of the Chinese Academy of Sciences, Beijing 100039, China. |
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Abstract: | Human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively. |
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Keywords: | Cathepsin K Matrix metalloproteinase 9 α Vβ 3 Natural inhibitor Bone resorption |
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