Modeling the effects of a simple immune system and immunodeficiency on the dynamics of conjointly growing tumor and normal cells |
| |
Authors: | Feizabadi Mitra Shojania Witten Tarynn M |
| |
Institution: | Physics Department, Seton Hall University, South Orange, NJ 07079, USA. shojanmi@shu.edu |
| |
Abstract: | In this paper, we develop a theoretical contribution towards the understanding of the complex behavior of conjoint tumor-normal cell growth under the influence of immuno-chemotherapeutic agents under simple immune system response. In particular, we consider a core model for the interaction of tumor cells with the surrounding normal cells. We then add the effects of a simple immune system, and both immune-suppression factors and immuno-chemotherapeutic agents as well. Through a series of numerical simulations, we illustrate that the interdependency of tumor-normal cells, together with choice of drug and the nature of the immunodeficiency, leads to a variety of interesting patterns in the evolution of both the tumor and the normal cell populations. |
| |
Keywords: | Aging tumor cell dynamics normal cell dynamics tumor-normal cell interactions chemotherapy Immune system Immunotherapy Immunodeficiency |
本文献已被 PubMed 等数据库收录! |
|