The distribution of viral blips observed in HIV-1 infected patients treated with combination antiretroviral therapy |
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Authors: | Percus Jerome K Percus Ora E Markowitz Martin Ho David D Di Mascio Michele Perelson Alan S |
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Institution: | (1) Courant Institute of Mathematical Sciences, New York University, New York, NY 10012, USA;(2) Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA;(3) Theoretical Division, MS K710, Los Alamos National Laboratory, Los Alamos, NM 87545, USA |
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Abstract: | Human immunodeficiency virus type 1 (HIV-1) infected patients treated with combination antiretroviral therapy frequently have
the level of HIV-1 RNA detectable in plasma driven below the lower limit of detection of current assays, 50 copies ml−1. Patients may continue to exhibit viral loads (VLs) below the assay limit for years, yet on some occasions the VL may be
above the limit of detection. Whether these ‘blips’ in VL are simply assay errors or are indicative of intermittent episodes
of increased viral replication is of great clinical concern. By analyzing the occurrence of viral blips in 123 treated HIV-infected
patients, we show that patients do not share a common probability distribution of blip amplitude and thus reject the hypothesis
that blips are solely due to assay variation.
Work performed under the auspices of the U.S. Department of Energy. |
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