Assessment of single-dose benzodiazepines on insulin secretion,insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind,placebo-controlled,randomized cross-over trial [ISRCTN08745124]期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Assessment of single-dose benzodiazepines on insulin secretion,insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind,placebo-controlled,randomized cross-over trial [ISRCTN08745124]

Authors:	Email author" target="_blank">Hugues?Chevassus Email author Isabelle?Mourand Nathalie?Molinier Bruno?Lacarelle Jean-Frédéric?Brun Pierre?Petit

Institution:	(1) Clinical Investigation Center, Saint-Eloi University Hospital, Section of Clinical Pharmacology, Montpellier, France;(2) Center for Pharmacology and Health Biotechnology, CNRS UMR 5160, Montpellier, France;(3) Department of Pharmacokinetics, La Timone University Hospital, Marseille, France;(4) Department of Clinical Physiology, Lapeyronie University Hospital, Montpellier, France

Abstract:	Background The present study aimed at investigating in healthy volunteers the effects of diazepam and clonazepam on beta-cell function, insulin sensitivity and glucose effectiveness based on the frequently sampled intravenous (0.5 gkg^-1) glucose tolerance test with minimal-model analysis.

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