Intracellular calcium changes induced by the endozepine triakontatetraneuropeptide in human polymorphonuclear leukocytes: role of protein kinase C and effect of calcium channel blockers期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Intracellular calcium changes induced by the endozepine triakontatetraneuropeptide in human polymorphonuclear leukocytes: role of protein kinase C and effect of calcium channel blockers

Authors:	Franca?Marino,Marco?Cosentino author-information" > author-information__contact u-icon-before" > mailto:marco.cosentino@uninsubria.it" title=" marco.cosentino@uninsubria.it" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Marco?Ferrari,Simona?Cattaneo,Giuseppina?Frigo,Anna?M?Fietta,Sergio?Lecchini,Gian?Mario?Frigo

Affiliation:	(1) Department of Clinical Medicine, Section of Experimental and Clinical Pharmacology, University of Insubria, Varese, Italy;(2) Department of Hematological, Pneumological and Cardiovascular Sciences, University of Pavia, Pavia, Italy;(3) Department of Internal Medicine and Therapeutics, Section of Pharmacology and Toxicology, University of Pavia, Pavia, Italy

Abstract:	Background The endozepine triakontatetraneuropeptide (TTN) induces intracellular calcium ([Ca⁺⁺]_i) changes followed by activation in human polymorphonuclear leukocytes (PMNs). The present study was undertaken to investigate the role of protein kinase (PK) C in the modulation of the response to TTN by human PMNs, and to examine the pharmacology of TTN-induced Ca⁺⁺ entry through the plasma membrane of these cells.

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