A new synthesis of the tripeptide Gly-His-Lys with antimicrobial activity |
| |
| Authors: | Assoc. Prof. Dr. M. Liakopoulou-Kyriakides C. Pachatouridis L. Ekateriuiadou V. P. Papageorgiou |
| |
| Affiliation: | (1) Department of Chemical Engineering, Section of Chemistry, Aristotle University of Thessaloniki, GR-54006 Thessaloniki, Greece;(2) Faculty of Chemistry, Aristotle University of Thessaloniki, GR-54006 Thessaloniki, Greece |
| |
| Abstract: | Summary A new solid phase synthesis of the growth-modulating tripeptide Gly-His-Lys is described. 2-Chlorotrityl chloride resin and 9-fluorenylmethoxycarbonyl-(Fmoc), 4-methyltrityl-(Mtt) protecting groups were used. The synthetic tripeptide was tested for its activity against bacteria, yeast and fungi. The in vitro effect of the tripeptide on DNA, RNA and protein synthesis was studied as well. |
| |
| Keywords: | Amino acids Tripeptide GHK Synthesis Antimicrobial activity |
| 本文献已被 SpringerLink 等数据库收录！ |
|
