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Synthesis and biological evaluation of menthol-based derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
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| Authors: | Ye Bin Bauer Shawn Buckman Brad O Ghannam Ameen Griedel Brian D Khim Seock-Kyu Lee Wheeseong Sacchi Karna L Shaw Kenneth J Liang Amy Wu Qingyu Zhao Zuchun |
| Affiliation: | Discovery Research, Berlex Biosciences, 2600 Hilltop Drive, PO Box 4099, Richmond, CA 94804-0099, USA. bin_ye@berlex.com |
| Abstract: | Compound 1 was identified by high throughput screening as a novel PAI-1 inhibitor. Optimization of the B and C-segments of 1 resulted in a series of structurally simplified compounds with improved potency. The synthesis and SAR data of these compounds are presented here. |
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