Synthesis and antifungal activity of 6-arylthio-/6-arylamino-4,7-dioxobenzothiazoles |
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Authors: | Ryu Chung Kyu Choi Ko Un Shim Ju Yeon You Hea Jung Choi Ik Hwa Chae Mi Jin |
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Institution: | College of Pharmacy, Ewha Womans University, Seodaemun-ku, Seoul 120-750, South Korea. cryu@mm.ewha.ac.kr |
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Abstract: | 6-Arylthio-/6-arylamino-4,7-dioxobenzothiazoles were synthesized and tested for in vitro antifungal activity against Candida species and Aspergillus niger. 6-Arylamino-4,7-dioxobenzothiazoles 5 and 6 showed, in general, more potent antifungal activity than 6-arylthio-4,7-dioxobenzothiazoles 3 and 4. The 6-arylamino-substituted compounds 5 and 6 exhibited the greatest activity. In contrast, 6-arylthio-, 2-/5-methyl- or 5-methoxy-moieties of compounds 3-4 did not improve their antifungal activity significantly. The results of this study suggest that 6-arylamino-4,7-dioxobenzothiazoles would be potent antifungal agents. |
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