Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues |
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| Authors: | Jew S Kim H J Kim M G Roh E Y Hong C I Kim J K Lee J H Lee H Park H |
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| Affiliation: | College of Pharmacy, Seoul National University, Korea. |
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| Abstract: | A series of C(7)-N-alkylaminoethyl-C(10), C(11)-methylenedioxy- and ethylenedioxy-camptothecin (3a-g, 4a-b) were prepared. Their syntheses and in vitro cytotoxicity were reported. Among 15 derivatives, 3a and 3b showed more potent cytotoxicity than Camptothecin, especially in CAOV-3 cell line. |
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