Inhibition of tyrosinase by indole compounds and reaction products protection by albumin |
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Authors: | Giacinto Urbani Laura Di Vito Dario Botti |
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Institution: | Istituto di Biologia Generale, Università degli Studi dell''Aquila, via Assergi 6, 67100 L''Aquila Italy |
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Abstract: | Tyrosinase activity decreases as the reaction proceeds and is inhibited by L-3,4-dihydroxyphenylalanine oxidation products. Indole and tryptophan inhibit tyrosinase reaction and bovine albumin protects against end-products(s) inhibiton or inactivation. Since the same tyrosinase reaction products are indole compounds and some authors reported the binding of indole derivatives with albumin, it is here suggested that indole intermediates of melanin synthesis inhibit or inactivate tyrosinase. |
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Keywords: | Tyrosinase inhibition Melanin synthesis Indole compound Albumin protection |
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