Cytogenetic and biochemical investigations on fibroblast cultures and clones with one and two active X chromosomes of a 69,XXY triploidy |
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Authors: | W. Vogel Thea Trautmann Heide Hörler S. Pentz |
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Affiliation: | 1. Abteilung Klinische Genetik der Universit?t Ulm, Oberer Eselsberg M 25, D-7900, Ulm/Donau, Federal Republic of Germany
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Abstract: | Bromodeoxyuridine replication patterns showed that fibroblasts from a 69,XXY triploidy carried either one or two early replicating X chromosomes. The activity of alpha-galactosidase A measured in single cells fell into two classes with a ratio of 1:2. Dilute plating produced clones of both types with the activity of alpha-galactosidase A corresponding to the number of active X chromosomes. To our knowledge, this is the first report on clones of a triploidy with different numbers of active X chromosomes, and on a gene-dosage effect of an X-linked gene using triploid cells with one active X as control. |
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