Theoretical study of mechano-chemical couplings in a compartmental enzyme system. I. Analytical treatment |
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Authors: | J M Valleton A J Grodzinsky E Selegny |
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Affiliation: | 1. School of Life Sciences, Jilin University, Changchun 130012, China;2. Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus OH 43210, USA;3. Department of Pharmacokinetics and Pharmacodynamics, Genentech, San Francisco 94080, CA, USA |
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Abstract: | This paper deals with theoretical aspects of the volume changes of a system in which diffusion, convection and reaction processes are coupled. This study involves a material able to swell in the presence of a chemical effector produced by an enzyme reaction. Three limiting factors of volume change rate were considered: fluid flow, diffusion or reaction limitations. Dimensionless diffusion-reaction and diffusion-convection parameters were introduced to allow quantitative predictions in limit cases. The steady states appear to be independent of convection processes; however, the transient states depend on diffusion, convection and reaction processes. |
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