Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) and prevent expression of the white winter coat |
| |
Authors: | Våge Dag Inge Fuglei Eva Snipstad Kristin Beheim Janne Landsem Veslemøy Malm Klungland Helge |
| |
Institution: | Norwegian University of Life Sciences (UMB), Department of Animal and Aquacultural Sciences, P.O. Box 5003, N-1432 As, Norway. daginge.vage@umb.no |
| |
Abstract: | We have characterized two mutations in the MC1R gene of the blue variant of the arctic fox (Alopex lagopus) that both incorporate a novel cysteine residue into the receptor. A family study in farmed arctic foxes verified that the dominant expression of the blue color phenotype cosegregates completely with the allele harboring these two mutations. Additionally to the altered pigment synthesis, the blue fox allele suppresses the seasonal change in coat color found in the native arctic fox. Consequently, these findings suggest that the MC1R/agouti regulatory system is involved in the seasonal changes of coat color found in arctic fox. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|