Scanning electron microscopic observations of chick embryo fibroblasts in vitro,with particular reference to the movement of cells under others

Summary Chick embryo fibroblasts in vitro have been studied with the scanning electron microscope. It has been found that when an advancing ruffled membrane reaches and crosses another cell, it retains contact with the substrate upon which it is moving. It is concluded that failure of contact inhibition is not explicable in terms of any hypothesis suggesting that advancing ruffled membranes adhere preferentially to the free (i. e. facing the nutrient medium) aspects of cells they encounter, rather than to their substrate.The Cambridge Scientific Instruments Stereoscan scanning electron microscope was provided by the Science Research Council (U. K.).