| 醛固酮对心室成纤维细胞分泌内皮素的影响 |
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| 引用本文： | Gong SZ,Liu PQ,Lu W,Wang TH,Fu SG,Tan Z,Pan JY. 醛固酮对心室成纤维细胞分泌内皮素的影响[J]. 生理学报, 2001, 53(1): 23-26 |
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| 作者姓名： | Gong SZ Liu PQ Lu W Wang TH Fu SG Tan Z Pan JY |
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| 作者单位： | 中山医科大学生理学教研室, |
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| 摘 要： | 用细胞培养、内皮素放射免疫测定和RT-PCR的方法,探讨醛固酮对心室成纤维细胞分泌内皮素的影响。结果显示,醛固酮(1×10
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| 关 键 词： | 醛固酮 螺旋内酯 内皮素放射免疫测定 ppET－1mRNA 心室成纤细胞 内皮素 |
| 修稿时间： | 2000-06-18 |
Effect of aldosterone on the secretion of endothelin by ventricular fibroblasts |
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| Gong S Z,Liu P Q,Lu W,Wang T H,Fu S G,Tan Z,Pan J Y. Effect of aldosterone on the secretion of endothelin by ventricular fibroblasts[J]. Acta Physiologica Sinica, 2001, 53(1): 23-26 |
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| Authors: | Gong S Z Liu P Q Lu W Wang T H Fu S G Tan Z Pan J Y |
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| Affiliation: | Department of Physiology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089. |
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| Abstract: | Using cell culture, radioimmunoassay for endothelin and RT-PCR, the effect of aldosterone on the endothelin secretion of ventricular fibroblasts was studied. The results showed that aldosterone (1 x 10(-7) mol/L) promoted the expression of ppET-1 mRNA, which began to increase in 2 hours and attained the highest level in 4 hours, thereafter decreased; aldosterone increased the endothelin level in ventricular fibroblasts and fibroblast conditioned growth medium (FCGM) as well, which was blocked by spironolactone (1 x 10(-6) mol/L), an aldosterone receptor antagonist. The results suggest that aldosterone can increase endothelin secretion by ventricular fibroblasts, which can be inhibited by its receptor antagonist spironolactone. |
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| Keywords: | aldosterone spironolactone radioimmunoassay for endothelin ppET 1 mRNA ventricular |
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