The effect of Ca on virus-cell fusion and permeability changes |
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Authors: | K J Micklem A Nyaruwe G M Alder C A Pasternak |
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Institution: | Department of Biochemistry, St George''s Hospital Medical School, Cranmer Terrace, London SW17 ORE UK |
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Abstract: | Sendai virus-mediated permeability changes in Lettre cells or red blood cells are affected by extracellular Ca2+ in the following way: the lag period to onset of permeability changes is lengthened and the subsequent extent of leakage is reduced. Ca2+ neither stimulates nor inhibits fusion of the viral envelope to the plasma membrane of Lettre cells or red blood cells. It is concluded that Ca2+ protects cells against virally-induced permeability changes in a manner not involving membrane fusion. |
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Keywords: | reprint requests to CAP |
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