Synthesis and pharmacological activities of xanthone derivatives as alpha-glucosidase inhibitors |
| |
Authors: | Liu Yan Zou Lan Ma Lin Chen Wen-Hua Wang Bo Xu Zun-Le |
| |
Institution: | School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, PR China. |
| |
Abstract: | Considerable interest has been attracted in xanthone and its derivatives because of their large variety of pharmacological activities. In this project, a series of hydroxylxanthones and their acetoxy and alkoxy derivatives were synthesized and evaluated as alpha-glucosidase inhibitors, aimed at clarifying the structure-activity correlation. The results indicated that these xanthone derivatives were capable of inhibiting in vitro alpha-glucosidase with moderate to good activities. Among them, polyhydroxylxanthones exhibited the highest activities and thus may be exploitable as a lead compound for the development of potent alpha-glucosidase inhibitors. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|