Pinocytic uptake of divinyl ether-maleic anhydride (pyran copolymer) and its failure to stimulate pinocytosis |
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| Authors: | Margaret K. Pratten Ruth Duncan Hazel C. Cable Reiner Schnee Helmut Ringsdorf John B. Lloyd |
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| Affiliation: | 1. Biochemistry Research Laboratory, Department of Biological Sciences, University of Keele, Keele, Staffs. ST5 5BG United Kingdom;2. Institute of Organic Chemistry, Johannes Gutenberg University, Mainz, Johan-Joachim-Becher-Weg 18-20, F.R.G. |
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| Abstract: | The effect of DIVEMA (pyran copolymer) and three DIVEMA derivatives on the pinocytic uptake of 125I-labelled PVP and colloidal 198Au by the rat visceral yolk sac and by rat peritoneal macrophages was studied in vitro. Contrary to expectations from some earlier data, there was no enhancement of pinocytosis and in some cases inhibition was seen. [14C]DIVEMA and 125I-labelled DIVEMA were accumulated rapidly by rat peritoneal macrophages, the results indicating that this is by an adsorptive pinocytic mechanism. |
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| Keywords: | DIVEMA, divinyl ether-maleic anhydride copolymer PVP, polyvinyl-pyrrolidone |
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