Interaction of insecticides with human plasma lipoproteins |
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Authors: | Badri P. Maliwal Frank E. Guthrie |
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Affiliation: | Toxicology Program, Department of Entomology, North Carolina State University, Raleigh, NC 27650 U.S.A. |
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Abstract: | The binding of chlorinated hydrocarbon, carbamate and organophosphate insecticides to human low density plasma lipoproteins (LDL) and high density plasma lipoproteins (HDL) was studied at pH 7.0 and 16°C and 26°C by equilibrium dialysis, difference spectra and fluorescence. The results suggest interaction to be a partitioning rather than a stoichiometric binding process. Distribution is related to lipid content and composition of the lipoproteins. The K-values vary from 3 × 105 M?1 for 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) to less than 10 M?1 for nicotine and aldicarb, and ΔGtr° is in the range of 7400 cal for DDT to less than 1000 cal for aldicarb and nicotine. The K and ΔGtr° are inversely related to the water solubility of the insecticides. A significant role of plasma lipoproteins in the transport of slightly water soluble insecticides is suggested. |
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Keywords: | DDT HDL high desity lipoproteins HSA human serum albumin LDL low density lipoproteins TLC thin-layer chromatography |
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