A peculiar toxicity manifested by platinum(II)amines in rats: Gastric distension after intraperitoneal administration |
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| Authors: | IA Roos DP Fairlie MW Whitehouse |
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| Institution: | 1. Department of Physical and Inorganic Chemistry, University of Adelaide Australia;2. Department of Experimental Pathology, The Australian National University, Canberra, ACT Australia |
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| Abstract: | Metoclopramide i.p. reduces the gastric distension consistently seen in rats given cisplatin i.p. at effective immunosuppressant doses (6 mg/kg). Many other immunosuppressant/oncolytic platinum amines also engendered gastric distension but certain dimers and 1,2-cyclohexanediaminoplatinum (II) compounds did not. This phenomenon appears to be due to paralysis of gastric emptying (without appetite suppression). |
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| Keywords: | DACH 1 2-cyclohexanediamine DDP GDI gastric distension index SI splenic index |
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