不同周龄Balb/c小鼠脏器质量及其变化趋势分析

目的:测定不同周龄Balb/c小鼠主要脏器质量、脏器系数,并进行比较。方法:取120只3周龄、5周龄、7周龄的Balb/c小鼠,雌雄各半,精确测量小鼠体重和主要脏器质量,计算脏器系数。结果:①雌性与雄性Balb/c小鼠脏器质量相比较:3周龄时肝、脾有显著差异(P0.05);5周龄时肝有非常显著差异(P0.01),脾、肺有显著差异(P0.05);7周龄时肝、肺及双肾有非常显著差异(P0.01),心、脾有显著差异(P0.05)。②雌性与雄性Balb/c小鼠脏器系数相比较:3周龄时肝、脾有显著差异(P0.05);5周龄时肝、脾有非常显著差异(P0.01),膀胱有显著差异(P0.05);7周龄时肺、双肾有非常显著差异(P0.01),脾、膀胱有显著差异(P0.05)。结论:随着周龄的增长,Balb/c雌、雄性小鼠之间,存在差异的脏器也在增多。

Measurement and Change Trend Analysis of Organ Weights inBalb/c Mice of Different Ages

Objective:To measure and compare the weight of main organs and the organ coefficient between male and femaleBalb/c mice of different ages.Methods:20 male and 20 female Balb/c mice at the ages of 3 weeks, 5 weeks and 7 weeks (total 120 mice)were used for the measurement of weight of main organs and organ coefficient.Results:1. Comparing the organ weight between femaleand male Balb/c mice, significant difference (P<0.05) for liver or spleen of mice of 3 weeks old, distinct significant differences (P<0.01)for liver and significant differences (P<0.05) for spleen or lungs of mice of 5 weeks old, distinct significant differences (P<0.01) for liver,lungs or double kidneys and significant differences (P<0.05) for heart or spleen of mice of 7 weeks old Balb/c were observed in the study.2. Comparing the organ coefficient between female and male Balb/c mice, significant differences (P<0.05) for liver or spleen of mice of 3weeks old, distinct significant differences (P<0.01) for liver or spleen and significant differences (P<0.05) for bladder of mice of 5 weeksold; distinct significant differences (P<0.01) for lungs or double kidneys and significant differences (P<0.05) for spleen or bladder of miceof 7 weeks old were observed in the study.Conclusion:As the growth of Balb/c mice, the difference of organs between female and malemice is increasingly notable.