| 选择性5-羟色胺再摄取抑制剂的临床应用进展 |
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| 引用本文： | 王申捷 孙凡 朱亮. 选择性5-羟色胺再摄取抑制剂的临床应用进展[J]. 现代生物医学进展, 2014, 14(3): 571-574 |
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| 作者姓名： | 王申捷 孙凡 朱亮 |
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| 作者单位： | 上海交通大学医学院药理学教研室上海交通大学医学科学研究院 |
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| 基金项目： | 上海市自然科学基金项目（12ZR1415700）；上海市重点学科开放课题（S30201）；国家“重大新药创制”科技重大专项（2009ZX09301-007） |
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| 摘 要： | 5-羟色胺(5-hydroxy tryptamine,5-HT)是中枢及外周神经系统中一种重要的神经递质。5-羟色胺转运体(5-HT transporter,5-HTT)可将5-HT再摄取,降低细胞外5-HT浓度,从而调节神经信号传导。5-HTT异常在某些精神疾病的发病中起重要作用。近年来选择性5-羟色胺再摄取抑制剂(selective serotonin reuptake inhibitors,SSRIs)在临床上的应用日趋广泛,如治疗抑郁症、焦虑症、抑郁和焦虑共病等常见的精神疾病。氟西汀、帕罗西汀、舍曲林、氟伏沙明和西酞普兰是目前临床上最常用的五种SSRIs,被誉为抗抑郁药的"五朵金花"。本文详细介绍近年来在临床上药物治疗抑郁症取得的成果以及这类药物的药效学、药动学、不良反应和相互作用等,并简要介绍SSRIs在其它疾病领域取得的应用进展。
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| 关 键 词： | 5-羟色胺；SSRIs；氟西汀；抑郁症；抗抑郁药 |
Clinical Application Progress of SSRIs |
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| WANG Shen-jie,SUN Fan,ZHU Liang. Clinical Application Progress of SSRIs[J]. Progress in Modern Biomedicine, 2014, 14(3): 571-574 |
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| Authors: | WANG Shen-jie SUN Fan ZHU Liang |
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| Abstract: | 5-HT is an important neurotransmitter in the central and peripheral nervous system. 5-HTT can reuptake 5-HT andreduce its extracellular concentration. Researchers have found that 5-HT anomaly playsan important role in the etiologies of some mentalillnesses. The clinical applications of SSRIs have been increasingly widespread these years, such as depression, anxiety disorder, panicdisorder, etc. Fluoxetine, Paroxetine, Sertraline, Fluvoxamine, Citalopram are the most popular medicines against depression. This articleintroduces the achievements of SSRIsand their pharmacodynamics, pharmacokinetics, side effects and interactions. The progress of thetreatments of other diseasesusing SSRIs is also included. |
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| Keywords: | 5-HT SSRIs Fluoxetine Depression Antidepressant |
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