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Thyrotropin releasing hormone: enhancement of DOPA activity in thyroidectomized rats |
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| Authors: | N P Plotnikoff A J Prange G R Breese I C Wilson |
| Affiliation: | 1. Experimental Therapy Division, Abbott Laboratories, North Chicago, Illinois, 60064, USA;2. Departments of Psychiatry and Pharmacology, and the Biological Sciences Research Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27514, USA |
| Abstract: | This study demonstrates that TRH potentiated the behavioral effects of DOPA-pargyline in thyroidectomized rats as well as in normal rats. This behavioral effect of TRH therefore can be considered to be independent of the thyroid gland in the DOPA potentiation test. Possible mechanisms and clinical implications are discussed. |
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