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Compounds similar to acyclovir. I. Synthesis of "complete" analogs of nucleosides |
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| Authors: | S V Kochetkova T L Tsilevich I P Smirnov I L Shchaveleva A A Khorlin |
| Abstract: | "Full" acyclic analogues of ribonucleosides, 1-(1,2,6-trihydroxy-4-oxahex-3-yl)thymine and -cytosine, 3- and 9-(1,2,6-trihydroxy-4-oxahex-3-yl)adenine, and 9-(1,2,6-trihydroxy-4-oxahex-3-yl)guanine, have been prepared by condensation of silylated nucleo-bases with 1,4,5,6-tetraacetoxy-3-oxahexane in the presence of Lewis acids followed by deacetylation. |
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