In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin |
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Authors: | Gieseler K Abdel-Dayem M Ségalat L |
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Affiliation: | Centro de Biología Molecular Severo Ochoá (CSIC-UAM), Madrid, Spain. |
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Abstract: | HeT-A elements are non-long terminal repeat retrotransposons added onto the Drosophila chromosome ends. We have investigated the formation in vitro of higher order structures by oligonucleotides derived from the 3' non-coding region of HeT-A elements and found that they are capable of forming G-quadruplex DNA. These results suggest that the 3' repeat region of HeT-A may structurally behave as the telomeric repeats common to a majority of eukaryotes. The presence of structural motifs shared by telomeres and centromeres and the implications of these findings for chromosome evolution are discussed. |
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