N-myc down-regulates activin A |
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Authors: | Breit S Rössler J Fotsis T Schweigerer L |
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Institution: | Abteilung H?matologie, Onkologie und Endokrinologie, Universit?ts-Kinderklinik Essen, Hufelandstrasse 55, Essen, 45122, Germany. |
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Abstract: | N-myc oncogene amplification is frequent in human neuroblastoma and predicts poor prognosis, but the molecular consequences have remained obscure. We report here that enhanced N-myc expression correlates with low or undetectable expression of activin A, but not other closely related members of the transforming growth factor-beta superfamily. N-myc interacts with the activin A promoter, eventually inducing down-regulation of activin A mRNA and protein. This study demonstrates for the first time N-myc-induced down-regulation of a gene implicated in signal transduction. Down-regulation of activin A could deprive neuroblastomas from a signal with growth-inhibitory activities toward the tumor and its stroma and thereby permit neuroblastoma progression. |
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