Antioxidant activity and protective effect on DNA cleavage of extracts from Cistus incanus L. and Cistus monspeliensis L. |
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Authors: | G Attaguile A Russo A Campisi F Savoca R Acquaviva N Ragusa A Vanella |
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Institution: | Institute of Pharmacology, University of Catania, Italy. |
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Abstract: | The genus Cistus includes many typical species of Mediterranean flora; Cistus species are used as antidiarrheics, as general remedies for treatment of various skin diseases in folk medicine and as anti-inflammatory
agents. These species contain flavonoids that are considered to be chain-breaking antioxidants. In this work, we have investigated
the effects of crude aqueous extracts from Cistus incanus and Cistus monspeliensis on DNA cleavage and their free-radical scavenging capacity. In addition, their effect on lipid peroxidation in rat liver
microsomes was evaluated. These extracts showed a protective effect on DNA cleavage and a dose-dependent free-radical scavenging
capacity; Cistus monspeliensis was more active than Cistus incanus; these results were confirmed by a significant inhibition of lipid peroxidation in rat liver microsomes. The experimental
evidence, therefore, suggests that because of their antioxidant activity these extracts may offer excellent photoprotection
for skin and may be useful in the treatment of human diseases where oxidative stress plays a key role.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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Keywords: | Cistus incanus Cistus monspeliensis DNA cleavage flavonoids free-radicals lipoperoxidation |
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