Fructose-2,6-bisphosphate increases the binding affinity of yeast phosphofructokinase to AMP |
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Authors: | R Kessler K Nissler W Schellenberger E Hofmann |
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Institution: | Institute of Physiological Chemistry, Karl-Marx-University, Leipzig, German Democratic Republic |
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Abstract: | At saturating concentrations of AMP four molecules of this ligand are bound per octamer of yeast phosphofructokinase. Fructose-2,6-bisphosphate increases the binding affinity of the enzyme to AMP. This indicates synergistic cooperation of the two allosteric activators in the binding process. The stoichiometry of binding is not altered by fructose-2,6-bisphosphate. |
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