Reduction Potentials of Imine-Substituted, Biologically Active Pyridines: Possible Relation To Activity |
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| Authors: | Peter Kovacic Mark A. Kassel Andre Csstonguay William R. Kem Benjamin A. Feinberg |
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| Affiliation: | a Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USAb School of Pharmacy, Laval University, Quebec, Canadac Department of Pharmacology, School of Medicine, University of Florida, Gainesville, FL, USA |
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| Abstract: | Cyclic voltammetry data were obtained for a number of biologically active compounds which incorporate imine substitution on the pyridine nucleus. The reductions in acid (iminium ion formation) were for the most part reversible, and in the range of—0.5 to—0.7 V. The toxic effect of these drugs is thought to be caused by the generation of reactive oxygen radicals that arise viacharge transfer, or by disruption of electron transport chains. |
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| Keywords: | Myosmine anabaseine dipyridyls terpyridyl reduction potentials electron transfer biomechanism |
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