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G2 chromosomal radiosensitivity in Fanconi's anemia
Authors:S B Bigelow  J M Rary  M A Bender
Institution:1. Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, BA 23501, USA;2. Medical Department, Brookhaven National Laboratory, Upton, NY 11973 U.S.A.
Abstract:Both the peripheral lymphocytes from 4 patients affected with the inherited disease Fanconi's anemia (FA), and tissue-culture fibroblasts from skin biopsies from 3 patients similarly affected were found to be about twice as sensitive to the induction of chromatid-type chromosomal aberrations by X-rays administratered in the G2 phase of the cell cycle as cells from normal controls. Using tritiated thymidine labelling of peripheral lymphocytes and of cultured fibroblasts, it was determined that 3 affected patients and 3 normal controls all had similar percent labeled mitoses (PLM) curves, so the increased induced aberration yields seen in the FA cells do not appear to be simply a consequences of a longer than normal G2 phase of the cell cycle.
Keywords:AT  ataxia telangiectasia  Fa  Fanconi's anemia  PHA  phytohemagglutinin  PLM  percent labeled mitoses
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