G2 chromosomal radiosensitivity in Fanconi's anemia |
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Authors: | S B Bigelow J M Rary M A Bender |
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Institution: | 1. Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, BA 23501, USA;2. Medical Department, Brookhaven National Laboratory, Upton, NY 11973 U.S.A. |
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Abstract: | Both the peripheral lymphocytes from 4 patients affected with the inherited disease Fanconi's anemia (FA), and tissue-culture fibroblasts from skin biopsies from 3 patients similarly affected were found to be about twice as sensitive to the induction of chromatid-type chromosomal aberrations by X-rays administratered in the G2 phase of the cell cycle as cells from normal controls. Using tritiated thymidine labelling of peripheral lymphocytes and of cultured fibroblasts, it was determined that 3 affected patients and 3 normal controls all had similar percent labeled mitoses (PLM) curves, so the increased induced aberration yields seen in the FA cells do not appear to be simply a consequences of a longer than normal G2 phase of the cell cycle. |
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Keywords: | AT ataxia telangiectasia Fa Fanconi's anemia PHA phytohemagglutinin PLM percent labeled mitoses |
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