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Variation in alternative splicing across human tissues |
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| Authors: | Gene Yeo Dirk Holste Gabriel Kreiman Christopher B Burge |
| Institution: | (1) Department of Biology, Center for Biological and Computational Learning, Massachusetts Institute of Technology, 02319 Cambridge, MA, USA;(2) Department of Brain and Cognitive Sciences, Center for Biological and Computational Learning, Massachusetts Institute of Technology, 02319 Cambridge, MA, USA |
| Abstract: | BackgroundAlternative pre-mRNA splicing (AS) is widely used by higher eukaryotes to generate different protein isoforms in specific cell or tissue types. To compare AS events across human tissues, we analyzed the splicing patterns of genomically aligned expressed sequence tags (ESTs) derived from libraries of cDNAs from different tissues. |
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