High resolution mid-prophase human chromosomes induced by echinomycin and ethidium bromide |
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| Authors: | Jeffrey R. Sawyer |
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| Affiliation: | (1) Department of Pathology, University of Arkansas for Medical Sciences, and Cytogenetics Laboratory, Arkansas Children's Hospital, 800 Marshall Street, 72202 Little Rock, AR, USA |
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| Abstract: | The antitumor antibiotic echinomycin (EM) was used in combination with ethidium bromide (EB) to induce high resolution mid-prophase chromosomes from amethopterin synchronized blood lymphocytes. With this combination of drugs, trypsin G-banded chromosomes showed over 1200 bands per haploid set in cells having a mid-prophase length of decondensation. |
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