Mapping of rat Chromosome 2 markers generated from chromosome-sorted DNA |
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| Authors: | Alan Y Deng Clara M Jackson Barbara Hoebee John P Rapp |
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| Institution: | (1) Department of Physiology and Molecular Medicine, Medical College of Ohio, 3000 Arlington Avenue, P.O. Box 10008, Toledo, Ohio 43699-0008, USA, US;(2) Department of Medicine, Medical College of Ohio, Toledo, Ohio 43699, USA, US;(3) Laboratory of Health Effects Research, National Institutes of Public Health and Environmental Protection, Bilthoven 3720 RA, The Netherlands, NL |
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| Abstract: | A quantitative trait locus (QTL) for blood pressure has recently been mapped to a region of roughly 30 cM on rat Chromosome
(Chr) 2 by linkage and by the use of congenic strains. For further fine mapping of the QTL, however, closely linked chromosome
markers residing in this 30-cM region are required. In the current work, 36 new markers were generated by screening rat Chr
2-sorted DNA libraries and subsequently mapped using five F2 populations. Combining new and existing markers, the marker density for the 30-cM region approaches, on average, one marker
per 1.1 cM.
Received: 11 April 1997 / Accepted: 12 May 1997 |
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